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KMID : 0359920110300050533
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Korean Journal of Nephrology
2011 Volume.30 No. 5 p.533 ~ p.536
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Slowly Progressing Thrombotic Microangiopathy during Two Years of Treatment with Sunitinib
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Kim Min-Young
Kang Na-Ree
Choi Hee-Jung
Kim Yoon-Jung
Jang Hye-Ryoun
Huh Woo-Seong
Kim Yoon-Goo
Kim Dae-Joong
Oh Ha-Young
Kwon Ghee-Young
Park Young-Suk
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Abstract
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A 75-year-old man with mild renal impairment was started on sunitinib for a metastatic gastrointestinal stromal tumor. After 7 months of this therapy, proteinuria became aggravated. Serum creatinine concentration was increased from 1.34 to 2.57 mg/dL 24 months after sunitinib administration. Hematologic features of thrombotic microangiopathy (TMA) were absent. Renal histology revealed endothelial swelling and plasmatic insudation of the glomeruli. Proteinuria and renal function improved after discontinuation of sunitinib. Our experience suggests that TMA associated with sunitinib can be diverse in onset and severity, and that the hematologic features of TMA may be absent.
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KEYWORD
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VEGF, Sunitinib, Thrombotic microangiopathy
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